Thyroid transcription factor-1 (TTF-1) expression and the efficacy of combination therapy with immune checkpoint inhibitors and cytotoxic chemotherapy in non-squamous non-small cell lung cancer
نویسندگان
چکیده
Background: Thyroid transcription factor-1 (TTF-1) is expressed in approximately 70% of lung adenocarcinomas and one the most reliable makers to distinguish primary adenocarcinoma from metastatic disease. TTF-1-negative status a poor prognostic factor, associated with efficacy immune checkpoint inhibitor (ICI) monotherapy. However, relationship between TTF-1 expression ICI plus chemotherapy still unclear.
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ژورنال
عنوان ژورنال: Translational lung cancer research
سال: 2023
ISSN: ['2226-4477', '2218-6751']
DOI: https://doi.org/10.21037/tlcr-23-331